Interferon-gamma release assay: use and misuse
نویسندگان
چکیده
منابع مشابه
[Interferon-gamma release assay in healthcare workers].
Agradecemos a los autores Ramos y cols. de Perú, su interés en los resultados de nuestro estudio. En Latinoamérica, dentro de las limitantes para el uso extensivo de tuberculina en la población mayor de 15 años están por un lado la dificultad de su interpretación por las altas tasas de vacunación con BCG en la infancia y por otro lado, los altos índices de infección que se vivieron al final del...
متن کاملInterferon-Gamma Release Assay Performance in Pulmonary and Extrapulmonary Tuberculosis
BACKGROUND The diagnosis of tuberculosis remains difficult. This study aimed to assess performance of interferon-gamma release assay (IGRA) in diagnosis of active tuberculosis (ATB) with pulmonary and extrapulmonary involvements, and to determine the diagnostic role of IGRA (T-SPOT.TB) and tuberculin skin test (TST) in BCG-vaccinated population. METHODS AND FINDINGS Two hundred twenty-six ATB...
متن کاملInterferon-gamma-release Assay Prevents Unnecessary Tuberculosis Therapy.
BACKGROUND The mass influx of immigrants from tuberculosis-endemic countries into Israel was followed by a considerable increase in the incidence of tuberculosis (TB). All contacts of active TB patients are obliged to be screened by tuberculin skin tests (TST) and, if found positive, prophylactic treatment is considered. OBJECTIVES To assess the utility of interferon-gamma (IFNγ)-release assa...
متن کاملThe role of interferon-gamma release assay in tuberculosis control.
Tuberculosis is still one of the major global public health threats. Countries with low incidence must focus on exhausting the reservoir of future cases by preventing reactivation. Therefore, it is important to identify and effectively treat those individuals who have latent tuberculosis infection and who may develop active disease. The tuberculin skin test has been the standard for detection o...
متن کاملPopulation tailored modification of tuberculosis specific interferon-gamma release assay
OBJECTIVES Blood-based Interferon-Gamma Release Assays (IGRA) identify Mycobacterium tuberculosis (MTB) sensitisation with increased specificity, but sensitivity remains impaired in human immunodeficiency virus (HIV) infected persons. The QuantiFERON-TB Gold In-Tube test contains peptide 38-55 of Rv2654c, based on data indicating differential recognition between tuberculosis patients and BCG va...
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ژورنال
عنوان ژورنال: Clinical Microbiology and Infection
سال: 2012
ISSN: 1198-743X
DOI: 10.1111/1469-0691.12025